Agricultural Science

Agricultural Science

ISSN: 2291-4471 (Print)    ISSN: 2291-448X (Online)

Volume 2 (2014), No. 2, Pages 12-20

DOI: 10.12735/as.v2i2p12

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Protective Role of Alginic Acid and Fucoidan from Nitric Oxide-Induced Oxidative Stress

Mi Jung So1  Hyun Young Kim2  Eun Ju Cho1 

1Department of Food Science and Nutrition, and Research Institute of Ecology for the Elderly, Pusan National University, Republic of Korea
2Department of Food Science, Gyeongnam National University of Science and Technology, Republic of Korea


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The protective activities of alginic acid and fucoidan from oxidative stress (OS) were investigated under cellular system using LLC-PK1 renal epithelial cells that are widely used for study cellular OS. The cellular OS in LLC-PK1 cells was induced by the free radical generators. The treatment of pyrogallol, sodium nitroprusside or 3-morpholinosydnonimine led to the production of superoxide anion (O2-), nitric oxide (NO) and peroxynitrite (ONOO-), respectively. The free radical generators decreased cell viability and elevated lipid peroxidation compared OSwith non-treated cells. However, the treatment of alginic acid and fucoidan attenuated OS significantly induced by NO, O2- and ONOO-, resulting in the significant increase of cell viability and inhibition of lipid peroxidation in concentration-dependent manner. In particular, fucoidan showed the stronger protective effect from oxidative stress than alginic acid. These results indicated that alginic acid and fucoidan played the protective role from NO-induced OS. The present study suggests the promising antioxidative agents of alginc acid and fucoidan with protective activity from free radical-induced OS.

Keywords: alginic acid, fucoidan, nitric oxide, peroxide, oxidative stress, antioxidant therapy, protective effect

To Cite this Article: So, M. J., Kim, H. Y., & Cho, E. J. (2014). Protective role of alginic acid and fucoidan from nitric oxide-induced oxidative stress. Agricultural Science, 2(2), 12-20.

Copyright © Mi Jung So et al.

Creative Commons License
This article is published under license to Science and Education Centre of North America. This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 International License.

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Protective Role of Alginic Acid and Fucoidan from Nitric Oxide-Induced Oxidative Stress